LOCALIZATION OF A PUTATIVE TUMOR-SUPPRESSOR GENE BY USING HOMOZYGOUS DELETIONS IN MELANOMAS

Authors
WEAVERFELDHAUS J GRUIS NA NEUHAUSEN S LEPASLIER D STOCKERT E SKOLNICK MH KAMB A
Citation
J. Weaverfeldhaus et al., LOCALIZATION OF A PUTATIVE TUMOR-SUPPRESSOR GENE BY USING HOMOZYGOUS DELETIONS IN MELANOMAS, Proceedings of the National Academy of Sciences of the United Statesof America, 91(16), 1994, pp. 7563-7567
Citations number
18
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
91
Issue
16
Year of publication
1994
Pages
7563 - 7567
Database
ISI
SICI code
0027-8424(1994)91:16<7563:LOAPTG>2.0.ZU;2-B
Abstract
The p21 region of human chromosome 9 is thought to contain a gene (MLM ) involved in genetic susceptibility to melanoma and a gene or genes t hat influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppres sor gene(s) have been isolated. A set of sequence-tagged sites in this region has been developed. By using these markers and others previous ly reported, the 9p21 region has been studied by physical mapping in 8 4 melanoma cell lines. A putative tumor suppressor gene, perhaps MLM i tself, has been localized to a region of less than 40 kb that lies pro ximal (centromeric) to the alpha-interferon gene cluster.