TEMPORAL DISTRIBUTION, LOCALIZATION AND METABOLISM OF ALL-TRANS-RETINOL, DIDEHYDRORETINOL AND ALL-TRANS-RETINAL DURING XENOPUS DEVELOPMENT

Citation
Jc. Kraft et al., TEMPORAL DISTRIBUTION, LOCALIZATION AND METABOLISM OF ALL-TRANS-RETINOL, DIDEHYDRORETINOL AND ALL-TRANS-RETINAL DURING XENOPUS DEVELOPMENT, Biochemical journal, 301, 1994, pp. 111-119
Citations number
31
Categorie Soggetti
Biology
Journal title
ISSN journal
02646021
Volume
301
Year of publication
1994
Part
1
Pages
111 - 119
Database
ISI
SICI code
0264-6021(1994)301:<111:TDLAMO>2.0.ZU;2-V
Abstract
Recently, the temporal and spatial distribution patterns of the retino id receptor ligands 9-cis-retinoic acid and all-trans-retinoic acid we re described in Xenopus embryos during early development [Creech Kraft , Schuh, Juchau and Kimelman (1994) Proc. Natl. Acad. Sci. U.S.A., in the press]. The present study demonstrates the presence and distributi on of their likely precursors, all-trans-retinol, didehydroretinol, di dehydroretinal and all-transretinal, as well as the occurrence of 4-ox o metabolites, in Xenopus embryos. The temporal and spatial distributi on patterns of all-trans-retinol, didehydroretinol and all-trans-retin al did not coincide with that observed for 9-cis-retinoic acid but, in certain regards, were similar to the patterns delineated for all-tran s-retinoic acid and all-trans-retinoyl beta-glucuronide. Evidence is p resented that 9-cis-retinoic acid can be synthesized from both all-tra ns-retinoic acid and all-trans-retinol in Xenopus embryos, suggesting that the difference between the distributions of 9-cis-retinoic acid a nd the other retinoids may be caused by selective synthesis and/or pro tein binding of the 9-cis isomer.