Eighty patients with non-insulin-dependent diabetes mellitus being tre
ated in a south Indian hospital were biopsied to confirm suspected non
diabetic renal disease (NDRD). The positive predictive value of the st
andard clinical indicators for NDRD in the presence or absence of diab
etic retinopathy was 54 and 87%, respectively. These values are higher
than those given by comparable studies in Western populations. This i
s probably due to a higher prevalence of NDRD in the population of sou
th India, and especially of proliferative glomerulonephritis, which wa
s found in 21.5% of the patients studied. Standard clinical predictors
of NDRD in diabetics have a high predictive value in the tropics wher
e there is a high prevalence of proliferative glomerulonephritis.