Sf. Meikle et al., CHLAMYDIA-TRACHOMATIS ANTIBODY-TITERS AND HYSTEROSALPINGOGRAPHY IN PREDICTING TUBAL DISEASE IN INFERTILITY PATIENTS, Fertility and sterility, 62(2), 1994, pp. 305-312
Objective: To determine if the number of diagnostic laparoscopies done
on women without tubal adhesive disease could be reduced by testing f
or tubal disease with Chlamydia trachomatis antibody titers and hyster
osalpingography (HSG), either singly or together. Design: Historical p
rospective chart review Setting: The Colorado Kaiser Permanente Reprod
uctive Endocrinology Clinic. Patients: All 703 infertility patients wh
o had C. trachomatis antibody titers done from March 2, 1988 to April
30, 1992. The final study group was comprised of 218 patients who had
antibody titers, HSG, and laparoscopy. Interventions: None. Main Outco
me Measure: Sensitivity, negative predictive value, and false-positive
rate were the test characteristics of interest. Tubal disease was ide
ntified by laparoscopy. Results: For HSG testing, the sensitivity was
78% and the negative predictive value was 85%. For C. trachomatis tite
rs, the sensitivity was also 78% and the negative predictive value was
82%. Ninety-five percent confidence intervals for sensitivity and neg
ative predictive value overlapped, indicating that there was no signif
icant difference. However, false-negative rates were the same for the
two tests, but false-positive rates were lowest for HSG and series tes
ting. Conclusions: To minimize false-positive tests and thus, to minim
ize unnecessary laparoscopies, HSG testing either alone or combined wi
th the C. trachomatis antibody titer as series tests yielded a signifi
cantly lower false-positive rate. In our study group, if both tests we
re negative, tubal disease was identified on laparoscopy in only 5% of
cases. Choice of most cost-effective test sequence will depend on who
bears the cost. Further studies of cost-benefit using well-defined te
sting sequences ace needed to determine if C. trachomatis antibody tit
ers in series with HSG would be more cost effective than HSG alone in
detecting tubal disease.