FIBRIN SEALANT IN LAPAROSCOPIC ADHESION PREVENTION IN THE RABBIT UTERINE HORN MODEL

Objective: To assess the effects of fibrin sealant on adhesions after laparoscopic surgery. Design: Standardized surgical trauma was induced in 60 female rabbits. The animals were randomized in three groups for different adhesion prevention treatment. Setting: University research laboratory. Interventions: After standardized trauma was induced, gro up 1 (n = 20) received no treatment, group 2 animals (n = 20) were inj ected in the abdominal cavity with 60 mt of Ringer's lactate, and huma n fibrin sealant was applied on the surgical lesions under laparoscopi c vision in group 3 (n = 20). Main Outcome Measures: Five weeks after laparoscopy, a laparotomy was performed, and the adhesions were scored . Results: Fourteen of 20 rabbits in the control group (70%) presented postoperative adhesions, 11 of 20 (55%) in the Ringer's group, and 5 of 20 (25%) in the fibrin sealant group. High-score adhesions were see n in 15% of cases in control and Ringer's group and in 5% of cases in the fibrin sealant group. Conclusions: When used during laparoscopic s urgery, fibrin sealant has a preventive effect on de novo postsurgical adhesions. To assess the efficacy in reproductive surgery, a trial on recurrent postsurgical adhesions is required.