E. Pozzi et al., AZITHROMYCIN VERSUS CLARITHROMYCIN IN THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC-BRONCHITIS, Current therapeutic research, 55(7), 1994, pp. 759-764
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
The patients, 206 adults with acute exacerbation of chronic bronchitis
, were randomly assigned to receive 500 mg of azithromycin once daily
for 3 days (n = 102) or 250 mg of clarithromycin twice daily for 7 day
s (n = 104). On days 4 and 8 after the start of treatment, patients re
ceiving azithromycin showed significantly fewer signs and symptoms of
bronchitis and on day 4 significantly more were rated as clinically im
proved than the patients in the clarithromycin group. Significantly mo
re pathogens were eradicated in azithromycin-treated patients (93%) th
an in clarithromycin-treated patients (75%). Side effects were reporte
d by four patients in the azithromycin group (abdominal pain, erythema
, and diarrhea) and by none of the clarithromycin-treated patients. It
is concluded that azithromycin is more effective than clarithromycin
in the treatment of acute exacerbation of chronic bronchitis.