SEPARATION OF THE OPTICAL ISOMERS OF A NEW 1,4-DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKER (LF 2.0254) BY LIQUID AND SUPERCRITICAL-FLUID CHROMATOGRAPHY

Authors
SIRET L MACAUDIERE P BARGMANNLEYDER N TAMBUTE A CAUDE M GOUGEON E
Citation
L. Siret et al., SEPARATION OF THE OPTICAL ISOMERS OF A NEW 1,4-DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKER (LF 2.0254) BY LIQUID AND SUPERCRITICAL-FLUID CHROMATOGRAPHY, Chirality, 6(5), 1994, pp. 440-445
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
6
Issue
5
Year of publication
1994
Pages
440 - 445
Database
ISI
SICI code
0899-0042(1994)6:5<440:SOTOIO>2.0.ZU;2-M
Abstract
The four optical isomers of a new calcium channel blocker LF 2.0254 (d eveloped by Laboratoires Fournier) are resolved by chromatography usin g chiral stationary phases. Two methods are proposed: the first one in volving two chiral stationary phases [(S)-N-(2-naphthyl)alanine, a Pir kle type CSP and Chiralcel OJ, a cellulose derived CSP] in the liquid chromatographic mode, the second one involving a single CSP (Chiralcel OJ) in the supercritical fluid chromatographic mode. (C) 1994 Wiley-L iss, Inc.