GENETIC-HETEROGENEITY IN TRUE HERMAPHRODITES - A REPORT OF 2 CASES

True hermaphrodites are identified from the presence of ambiguous geni talia with both ovarian and testicular tissue. Two cases presented bel ow had a 46, XX chromosome pattern, cryptorchidism and undescended tes tes. Both cases showed an absence of secondary sexual characteristics and presence of bilateral breasts and a uterus. The gonads in case 1 w ere an ovotestis and testis (left side) and in case 2 were an ovary an d testis (right side). Case 1 was analyzed for a sex-determining regio n on the Y chromosome (SRY) and was negative. Phenotypic, gonadal and molecular studies suggest that 46, XX true hermaphroditism is It genet ically heterogeneous condition.