Human beings are by nature social animals, but for some, social scruti
ny is a source of extreme anguish. Those with social phobia, for examp
le, suffer excessive and often disabling concern about potential and r
eal social-evaluative threat. As new and effective therapies for this
condition are pursued, there is a simultaneous movement to extend the
understanding of this disorder's etiology. In psychiatry, as in the re
st of medicine, this development of new treatments often occurs in par
allel with increasing sophistication about causes of illness. Advances
in one area typically inform and predictably lead to advances in the
other. Social phobia is recognized as a relatively common and signific
antly impairing anxiety disorder. As with other psychiatric disorders,
emerging models of the etiology of social phobia are derived from con
verging evidence of interacting biological and environmental contribut
ions. Current theories regarding the evolution of social phobia will b
e addressed, including biological preparedness to fear scrutiny by oth
ers, genetically transmitted predisposition to fear acquisition, nonge
netic familial and environmental factors, as well as other possible ca
uses and antecedents. Additionally, we describe recent work on behavio
ral inhibition in infancy as an identifiable early marker of proneness
to the development of anxiety disorders, including social phobia.