EFFECT OF CONTINUOUS ARTERIOVENOUS HEMODIAFILTRATION ON THE PHARMACOKINETICS OF FLUCONAZOLE

In critically ill patients with acute renal failure, continuous arteri ovenous hemodiafiltration (CAVHD) has become an increasing popular sup portive technique. An adult with acute renal failure during CAVHD ther apy received fluconazole. Drug clearance by the hemodiafilter system a nd its total body clearance during the CAVHD period were 23-28 ml/minu te and 22 ml/minute, respectively, indicating that the rate of systemi c clearance was solely dependent on CAVHD in this patient. Total body clearance, area under the curve, and half-life values for this patient closely resembled those in healthy subjects. These observations sugge st that patients treated with fluconazole during CAVHD should receive standard maintenance dosages, and neither supplementation nor dosage a djustment is required.