Dp. Nicolau et al., EFFECT OF CONTINUOUS ARTERIOVENOUS HEMODIAFILTRATION ON THE PHARMACOKINETICS OF FLUCONAZOLE, Pharmacotherapy, 14(4), 1994, pp. 502-505
In critically ill patients with acute renal failure, continuous arteri
ovenous hemodiafiltration (CAVHD) has become an increasing popular sup
portive technique. An adult with acute renal failure during CAVHD ther
apy received fluconazole. Drug clearance by the hemodiafilter system a
nd its total body clearance during the CAVHD period were 23-28 ml/minu
te and 22 ml/minute, respectively, indicating that the rate of systemi
c clearance was solely dependent on CAVHD in this patient. Total body
clearance, area under the curve, and half-life values for this patient
closely resembled those in healthy subjects. These observations sugge
st that patients treated with fluconazole during CAVHD should receive
standard maintenance dosages, and neither supplementation nor dosage a
djustment is required.