VISUAL OUTCOMES OF MACULAR RETINOBLASTOMA AFTER EXTERNAL-BEAM RADIATION-THERAPY

Purpose: To determine the risk factors that influence the visual outco mes of patients with macular retinoblastoma who are treated with radia tion therapy. Methods: The medical records of all patients with macula r retinoblastoma treated with radiation therapy between 1980 and 1990 were reviewed. Ten patients were entered into the study. Features anal yzed included patient age, laterality of eye involvement, location and size of macular tumor(s) at the time of diagnosis, treatment course, and most recent visual acuity. Findings: Ten of 11 eyes (10 patients) were successfully treated with external beam radiation. Eight patients obtained Visual acuities ranging from 20/25 to 20/100; two patients h ad visual acuities of 20/200 or less. The best visual acuities were no ted in patients whose tumor(s) did not involve the fovea and were rela tively small. The worse visual acuities were noted in patients with bi nocular vision whose tumors invaded the fovea and were larger in size. In two of three patients in whom both eyes were retained, superimpose d amblyopia developed in the eye with macular retinoblastoma. Conclusi on: The authors' findings indicate that most patients with macular ret inoblastoma who are treated with external beam radiation have favorabl e visual outcomes, but final visual acuity depends on the size of the tumor and involvement of the fovea. Patients in whom both eyes are ret ained are predisposed to further visual loss from amblyopia.