FACIAL MORPHOMETRY OF ECUADORIAN PATIENTS WITH GROWTH-HORMONE RECEPTOR DEFICIENCY LARON SYNDROME

Authors
SCHAEFER GB ROSENBLOOM AL GUEVARAAGUIRRE J CAMPBELL EA ULLRICH F PATIL K FRIAS JL
Citation
Gb. Schaefer et al., FACIAL MORPHOMETRY OF ECUADORIAN PATIENTS WITH GROWTH-HORMONE RECEPTOR DEFICIENCY LARON SYNDROME, Journal of Medical Genetics, 31(8), 1994, pp. 635-639
Citations number
34
Categorie Soggetti
Genetics & Heredity
Journal title
Journal of Medical Genetics → ACNP
ISSN journal
00222593
Volume
31
Issue
8
Year of publication
1994
Pages
635 - 639
Database
ISI
SICI code
0022-2593(1994)31:8<635:FMOEPW>2.0.ZU;2-V
Abstract
Facial morphometry using computerised image analysis was performed on patients with growth hormone receptor deficiency (Laron syndrome) from an inbred population of southern Ecuador. Morphometrics were compared for 49 patients, 70 unaffected relatives, and 14 unrelated persons. P atients with growth hormone receptor deficiency showed significant dec reases in measures of vertical facial growth as compared to unaffected relatives and unrelated persons with short stature from other causes. This report validates and quantifies the clinical impression of fores hortened facies in growth hormone receptor deficiency.