SYNTHESIS OF SPIROKETAL-MODIFIED AVERMECTIN ANALOGS - 23-NOR-23-OXA-AVERMECTIN AND 23-NOR-23-THIA-AVERMECTIN

Authors
MEINKE PT OCONNOR SP FISHER MH MROZIK H
Citation
Pt. Meinke et al., SYNTHESIS OF SPIROKETAL-MODIFIED AVERMECTIN ANALOGS - 23-NOR-23-OXA-AVERMECTIN AND 23-NOR-23-THIA-AVERMECTIN, Tetrahedron letters, 35(30), 1994, pp. 5343-5346
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
30
Year of publication
1994
Pages
5343 - 5346
Database
ISI
SICI code
0040-4039(1994)35:30<5343:SOSAA->2.0.ZU;2-O
Abstract
The concise synthesis of avermectin analogs wherein the C23 carbon has been excised and replaced with an oxygen or sulfur atom is described. The new, heteroatom-substituted avermectins represent isosteres of 22 ,23-dihydro-avermectin B-1a and, in the case of the sulfoxides and sul fones, are isosteric to avermectin B-2a, These new avermectins bear di verse functionality at C24 and C25.