BIOSYNTHESIS OF (+)-EPICUBENOL

Authors
CANE DE TANDON M
Citation
De. Cane et M. Tandon, BIOSYNTHESIS OF (+)-EPICUBENOL, Tetrahedron letters, 35(30), 1994, pp. 5355-5358
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
30
Year of publication
1994
Pages
5355 - 5358
Database
ISI
SICI code
0040-4039(1994)35:30<5355:BO(>2.0.ZU;2-7
Abstract
Incubation of [6-H-2]FPP (14a) with epicubenol synthase isolated from Streptomyces sp. LL-B7 gave epicubenol (1c) labeled at D-9 as establis hed by 2H NMR. These results confirm the involvement of a predicted 1, 2-hydride shift in the mechanism of formation of 1.