SYNTHESIS OF (2S,4S)-5-FLUOROLEUCINE

Authors
MOODY CM STARKMANN BA YOUNG DW
Citation
Cm. Moody et al., SYNTHESIS OF (2S,4S)-5-FLUOROLEUCINE, Tetrahedron letters, 35(30), 1994, pp. 5485-5488
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
30
Year of publication
1994
Pages
5485 - 5488
Database
ISI
SICI code
0040-4039(1994)35:30<5485:SO(>2.0.ZU;2-O
Abstract
(2S,4S)-5-Fluoroleucine, has been prepared by stereospecific synthesis using (2S)pyroglutamic acid as a chiral template. Protection was requ ired in the synthesis to prevent cyclisation to a proline derivative d uring the fluorination step.