We assessed the value of therapeutic reevaluation and additional pharm
acotherapy in medically intractable children referred for epilepsy sur
gery. In 21 children with antiepileptic drug treatment omissions, corr
ecting the omission was ineffective in 19 (90%). Two children (10%), b
oth of whom had structural lesions, achieved significant seizure contr
ol with high-dose carbamazepine monotherapy. Therapeutic reevaluation
is indicated in all medically intractable children prior to epilepsy s
urgery.