ESTROGEN-RECEPTORS (ER) IN HUMAN BREAST-CANCER - THE SIGNIFICANCE OF A NEW PROGNOSTIC FACTOR BASED ON BOTH ER PROTEIN AND ER MESSENGER-RNA CONTENTS

Authors
GOTTELAND M MAY E MAYLEVIN F CONTESSO G DELARUE JC MOURIESSE H
Citation
M. Gotteland et al., ESTROGEN-RECEPTORS (ER) IN HUMAN BREAST-CANCER - THE SIGNIFICANCE OF A NEW PROGNOSTIC FACTOR BASED ON BOTH ER PROTEIN AND ER MESSENGER-RNA CONTENTS, Cancer, 74(3), 1994, pp. 864-871
Citations number
30
Categorie Soggetti
Oncology
Journal title
Cancer → ACNP
ISSN journal
0008543X
Volume
74
Issue
3
Year of publication
1994
Pages
864 - 871
Database
ISI
SICI code
0008-543X(1994)74:3<864:E(IHB->2.0.ZU;2-7
Abstract
Background. The response to endocrine therapy is not entirely predicta ble from the estrogen receptor (ER) and progesterone receptor (PgR) st atus of primary breast tumors. The authors previously proposed a new p rognostic factor, ER.R, which was based on both ER protein and mRNA le vels. A previous analysis of 88 primary breast carcinomas showed that ER.R permits the identification of a subset of ER-positive women with a higher risk of early relapse. The purpose of the present study was t o confirm the prognostic significance of ER.R.