ADJUVANT CHEMOTHERAPY FOR TREATMENT OF UNRESECTABLE AND METASTATIC ANGIOMATOID MALIGNANT FIBROUS HISTIOCYTOMA

Angiomatoid malignant fibrous histiocytoma (AMFH) is a low grade soft tissue sarcoma usually treated with surgery alone. Only one adult pati ent has been treated with systemic chemotherapy. The authors report a case of unresectable, metastatic AMFH treated initially with vincristi ne, doxorubicin, dactinomycin, and cyclophosphamide. A complete respon se at the metastatic site and a marked reduction in the size of the pr imary tumor allowed complete surgical excision 7 months after treatmen t was initiated. The patient remains disease free 19 months after bein g diagnosed. It was concluded that systemic chemotherapy may be effect ive in patients with AMFH.