ERYTHEMA-MULTIFORME-LIKE, URTICARIAL PAPULAR AND PLAQUE ERUPTIONS FROM BUFEXAMAC - REPORT OF 4 CASES

4 patients developed an erythema-multiforme-like reaction following ac ute contact dermatitis from 2 different bufexamac-containing topical p reparations. Histologically, the lesions did not show changes that wer e typical of erythema multiforme. Patch testing gave positive reaction s to bufexamac at 1, 2, 3 and 4 days. The histological picture of 2 po sitive test reactions was suggestive of a drug reaction in the 1st, an d of an acute eczematous reaction in the 2nd, case. A systemic allergi c reaction with spread of lesions could have been involved, following percutaneous absorption of the allergen.