CALCITONIN-PRODUCING INSULINOMA - CLINICAL, IMMUNOCYTOCHEMICAL AND CYTOGENETICAL STUDY

Authors
BUGALHO MJGM ROQUE L SOBRINHO LG HOOG A NUNES JFM ALMEIDA JMM LEITAO CN SANTOS JR PEREIRA MC SANTOS MA SOARES J
Citation
Mjgm. Bugalho et al., CALCITONIN-PRODUCING INSULINOMA - CLINICAL, IMMUNOCYTOCHEMICAL AND CYTOGENETICAL STUDY, Clinical endocrinology, 41(2), 1994, pp. 257-260
Citations number
16
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Clinical endocrinology → ACNP
ISSN journal
03000664
Volume
41
Issue
2
Year of publication
1994
Pages
257 - 260
Database
ISI
SICI code
0300-0664(1994)41:2<257:CI-CIA>2.0.ZU;2-D
Abstract
The case of a patient with a large goitre associated with hypercalcito ninaemia and fasting hypoglycaemia is reported. Pentagastrin (PG) test was negative. Repeated measurements of fasting glycaemia, insulin and C peptide established the diagnosis of insulinoma. After localization by endoscopic ultrasonography, a distal pancreatectomy was performed and a small insulinoma was recovered. Glycaemia and calcitonin (CT) be came normal. The tumour cells displayed a strong immunoreactivity for insulin and CT. Cytogenetical evaluation of the tumour revealed a tran slocation t(1;9) (p13;p22).