EXPRESSION OF XENOBIOTIC-METABOLIZING CYTOCHROME-P450 FORMS IN HUMAN ADULT AND FETAL LIVER

Authors
HAKKOLA J PASANEN M PURKUNEN R SAARIKOSKI S PELKONEN O MAENPAA J RANE A RAUNIO H
Citation
J. Hakkola et al., EXPRESSION OF XENOBIOTIC-METABOLIZING CYTOCHROME-P450 FORMS IN HUMAN ADULT AND FETAL LIVER, Biochemical pharmacology, 48(1), 1994, pp. 59-64
Citations number
42
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
48
Issue
1
Year of publication
1994
Pages
59 - 64
Database
ISI
SICI code
0006-2952(1994)48:1<59:EOXCFI>2.0.ZU;2-S
Abstract
Expression of human cytochrome P450 (CYP) genes in human adult and fet al liver were studied using the reverse transcriptase-polymerase chain reaction (RT-PCR) method. In adult liver mRNA of CYPs 1A1, 1A2, 2A6/2 A7, 2B6/2B7, 2C8-19, 2D6, 2E1, 3A3/3A4 and 3A7 were detected while CYP s 2F1 and 4B1 were absent. In fetal liver mRNA of CYPs 2C8, 2D6, 3A3/3 A4 and 3A7 were found but all other forms studied were undetectable. T he results provide a comprehensive qualitative picture of the expressi on of CYP genes in families CYP1 through CYP4 in human adult and fetal liver.