REDUCTION IN SIZE OF A THYROTROPIN-SECRETING PITUITARY-ADENOMA TREATED WITH OCTREOTIDE ACETATE (SOMATOSTATIN ANALOG)

We present a 55-year-old female with a thyrotropin (TSH)-secreting pit uitary adenoma who had been treated with somatostatin analog octreotid e acetate (SMS 201-995) for 4 months. Subcutaneous injection of 100 mu g octreotide acetate twice daily resulted in significant reduction of the TSH, thyroid hormone, and tumor size. During the treatment, there was no evidence of any side effects. We may conclude that octreotide acetate administration is an effective treatment in patients with TSH- secreting pituitary adenoma for suppressing TSH hypersecretion and red ucing the size of the tumor.