R. Rodriguezarnaiz et Jh. Aranda, ACTIVITY OF AROMATIC-AMINES IN THE EYE - W W+ SOMATIC ASSAY OF DROSOPHILA-MELANOGASTER/, Environmental and molecular mutagenesis, 24(1), 1994, pp. 75-79
Aromatic amines represent a category of classical environmental hazard
s which require biotransformation in order to exert their mutagenic an
d carcinogenic effects. The mutagenic activity of several aromatic ami
nes was tested by means of the w/w(+) somatic assay of Drosophila mela
nogaster employing a wild-type strain Leiden Standard (LS) and an inse
cticide-resistant stock Hikone-R (HK-R). Four monocyclic-ortho-anisidi
ne (O-AN), ortho-toluidine (O-TO), 2,4-diaminoanisole (2,4-DAA) and 4-
nitro-o-phenylenediamine (4-N-o-PDA), and one bicyclic- 4,4'-oxidianil
ine (4,4'-ODA) aromatic amines were tested by chronic exposure. Two se
parate experiments were run, and concurrent controls were treated with
the solvent mixture. Results show that the ortho-anilines (O-AN and O
-TO) were active in the assay, while the diamines containing a methoxy
(2,4-DAA) or a nitro group (4-N-o-PDA) were inactive. The bicyclic ar
omatic amine, 4,4'-ODA, was the most potent. The genotoxic responsiven
ess of both strains was very similar. (C) 1994 Wiley-Liss, Inc.