MOST material in the Solar System has an isotopic composition that rep
resents an average of the different stars that contributed material to
the protostellar cloud. Primitive meteorites, on the other hand, pres
erve grains that retain the isotopic signatures of their individual st
ellar sources(1) and thus provide valuable insight into stellar and ga
lactic evolution, nucleosynthesis, and solar nebular processes. A larg
e number of pre-solar silicon carbide, graphite and diamond grains hav
e now been isolated(1,2), but only three interstellar oxide grains hav
e hitherto been recovered(3-7), even though oxygen-rich stars are beli
eved to be the dominant source of dust in the Galaxy(8,9). We report h
ere the isolation of 21 interstellar oxide grains from the Tieschitz m
eteorite. The grains exhibit a wide range of oxygen isotope compositio
ns, indicating that they originated in several distinct stellar source
s having different masses and initial compositions. There is also evid
ence for the presence of the short-lived radionuclide Al-26 in nine of
the grains at the time they formed. Although the isotopic composition
s of many of the grains are consistent with both observations and theo
retical models of oxygen-rich red giant stars, a significant fraction
have no observed stellar counterpart.