STRUCTURES possessing spatial asymmetry should act as pumps in the pre
sence of dissipation alone(1-4), without the need for macroscopic forc
es or temperature differences(5) to drive vectorial motion. It has bee
n shown theoretically(2-4,6,7) that particles subjected to an asymmetr
ic periodic potential can display net directional motion even if the s
pace-averaged forte is zero. Here we demonstrate such behaviour experi
mentally. We have studied the behaviour of colloidal particles suspend
ed in solution and exposed to a sawtooth dielectric potential which is
turned on and off periodically. The particles exhibit net motion with
a velocity that depends on their size, suggesting applications in sep
aration processes for objects in the size range 0.1-5 mu m-a range tha
t includes biological structures such as viruses, cells and chromosome
s(8). We furthermore point out the analogy between our device and moto
r protein assemblies.