INFLUENCE OF THYROTROPIN-RELEASING-HORMON E (TRH) AND HISTIDYL-PROLINE-DIKETOPIPERAZINE [CYCLO(HIS PRO)] ON ENZYME-SECRETION FROM ISOLATED RAT EXOCRINE PANCREATIC ACINAR-CELLS

Authors
KEMMER TP DUNTAS L MUNZ W MALFERTHEINER P
Citation
Tp. Kemmer et al., INFLUENCE OF THYROTROPIN-RELEASING-HORMON E (TRH) AND HISTIDYL-PROLINE-DIKETOPIPERAZINE [CYCLO(HIS PRO)] ON ENZYME-SECRETION FROM ISOLATED RAT EXOCRINE PANCREATIC ACINAR-CELLS, Leber, Magen, Darm, 24(4), 1994, pp. 156
Citations number
NO
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Leber, Magen, Darm → ACNP
ISSN journal
03008622
Volume
24
Issue
4
Year of publication
1994
Database
ISI
SICI code
0300-8622(1994)24:4<156:IOTE(A>2.0.ZU;2-2
Abstract
The effect of thyrotropin-releasing hormone (TRH) and histidyl-proline -diketopiperazine [cyclo (His-Pro), CHP] on amylase secretion from iso lated rat exocrine pancreatic acinar cells was investigated. TRH showe d a dose-dependent inhibition of carbachol-stimulated amylase secretio n with a maximum of 24% at a concentration of 10(-11) M (p < 0.05). Ba sal amylase release was not affected in concentrations from 10(-13) M to 10(-8) M. CHP did not influence basal or carbachol-stimulated pancr eatic secretion in vitro. These results suggest that TRH in contrast t o CHP may play a role in the paracrine regulation of exocrine pancreat ic secretion.