Study Design. The effects of pedicle screw size (major diameter and le
ngth) on fixation stiffness in osteoporotic and nonosteoporotic verteb
rae were evaluated in vitro. Methods. Lumbar vertebrae were obtained f
rom two fresh frozen human spines. Bone mineral densities were determi
ned using dual energy radiograph absorptiometry, followed by nondestru
ctive mechanical testing of the specimens instrumented with pedicle sc
rews. A loading technique was used that more closely mimics loading of
pedicle screws in vivo. Results. Testing revealed that for good quali
ty bone, screw size had a significant effect on fixation stiffness, bu
t the effect of penetration depth depended on pedicle fill, and vice v
ersa. In nonosteoporotic bone, the use of a longer screw increased fix
ation stiffness if the screw filled up the pedicle by 70% or more. The
use of wider screws increased the fixation stiffness if the penetrati
on depth was 80% or more. Conclusion. Screw size had little or no effe
ct on fixation stiffness in osteoporotic bone.