CAPTOPRIL AND ITS PROBABLE CONTAMINANTS - NMR AND MS FEATURES OF ANALYTICAL VALUE

Authors
CASY AF DEWAR GH
Citation
Af. Casy et Gh. Dewar, CAPTOPRIL AND ITS PROBABLE CONTAMINANTS - NMR AND MS FEATURES OF ANALYTICAL VALUE, Journal of pharmaceutical and biomedical analysis, 12(7), 1994, pp. 855-861
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
12
Issue
7
Year of publication
1994
Pages
855 - 861
Database
ISI
SICI code
0731-7085(1994)12:7<855:CAIPC->2.0.ZU;2-E
Abstract
The 400 MHz H-1 NMR spectrum of captopril in a variety of solvents is analysed and compared with those of epicaptopril and its disulphide an alogue. A method for detecting isomeric and oxidative impurities by ex amination of a H-1 NMR spectrum of captopril in DMSO-d6 is proposed. C -13 NMR and MS data enable differentiation of captopril from its disul phide analogue but not from its diastereoisomer epicaptopril.