J. Russell et al., THE ASSESSMENT OF THE HO-CENTER-DOT SCAVENGING ACTION OF THERAPEUTIC AGENTS, Journal of pharmaceutical and biomedical analysis, 12(7), 1994, pp. 863-866
A new method is reported for the assessment of the HO. scavenging acti
on of therapeutic agents. It is based on the photolysis of zinc oxide
and has a detection limit of 3.3%. The scavenging order of the compoun
ds tested was penicillamine > rentiapril > ascorbic acid > cysteine >
glutathione > thiomalic acid > N-acetylcysteine > myocrysin > methioni
ne. None were as effective as DMSO. It is argued that these compounds
can have an in vivo protective effect where HO. is produced from oxida
nt producing cells, thus limiting radical induced damage.