THE ASSESSMENT OF THE HO-CENTER-DOT SCAVENGING ACTION OF THERAPEUTIC AGENTS

Authors
RUSSELL J NESS J CHOPRA M MCMURRAY J SMITH WE
Citation
J. Russell et al., THE ASSESSMENT OF THE HO-CENTER-DOT SCAVENGING ACTION OF THERAPEUTIC AGENTS, Journal of pharmaceutical and biomedical analysis, 12(7), 1994, pp. 863-866
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
12
Issue
7
Year of publication
1994
Pages
863 - 866
Database
ISI
SICI code
0731-7085(1994)12:7<863:TAOTHS>2.0.ZU;2-Y
Abstract
A new method is reported for the assessment of the HO. scavenging acti on of therapeutic agents. It is based on the photolysis of zinc oxide and has a detection limit of 3.3%. The scavenging order of the compoun ds tested was penicillamine > rentiapril > ascorbic acid > cysteine > glutathione > thiomalic acid > N-acetylcysteine > myocrysin > methioni ne. None were as effective as DMSO. It is argued that these compounds can have an in vivo protective effect where HO. is produced from oxida nt producing cells, thus limiting radical induced damage.