5-DIETHOXYPHOSPHORYL-5-METHYL-1-PYRROLINE N-OXIDE (DEPMPO) - A NEW PHOSPHORYLATED NITRONE FOR THE EFFICIENT IN-VITRO AND IN-VIVO SPIN-TRAPPING OF OXYGEN-CENTERED RADICALS

Authors
FREJAVILLE C KAROUI H TUCCIO B LEMOIGNE F CULCASI M PIETRI S LAURICELLA R TORDO P
Citation
C. Frejaville et al., 5-DIETHOXYPHOSPHORYL-5-METHYL-1-PYRROLINE N-OXIDE (DEPMPO) - A NEW PHOSPHORYLATED NITRONE FOR THE EFFICIENT IN-VITRO AND IN-VIVO SPIN-TRAPPING OF OXYGEN-CENTERED RADICALS, Journal of the Chemical Society, Chemical Communications, (15), 1994, pp. 1793-1794
Citations number
18
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
15
Year of publication
1994
Pages
1793 - 1794
Database
ISI
SICI code
0022-4936(1994):15<1793:5N(-AN>2.0.ZU;2-O
Abstract
5-Diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO), a newly sy nthesized spin trap, is used for the in vitro spin trapping of hydroxy l and superoxide radicals, and though the spin trapping rates are clos e to those reported for 5,5-dimethyl-1 -pyrroline N-oxide (DMPO),the D EPMPO-superoxide spin adduct is significantly more persistent than its DMPO analogue, a difference which allows the detection of superoxide during the reperfusion of ischaemic isolated rat hearts.