EFFECT OF ANALYTIC UNCERTAINTY OF CONVENTIONAL AND POINT-OF-CARE ASSAYS OF ACTIVATED PARTIAL THROMBOPLASTIN TIME ON CLINICAL DECISIONS IN HEPARIN-THERAPY
M. Werner et al., EFFECT OF ANALYTIC UNCERTAINTY OF CONVENTIONAL AND POINT-OF-CARE ASSAYS OF ACTIVATED PARTIAL THROMBOPLASTIN TIME ON CLINICAL DECISIONS IN HEPARIN-THERAPY, American journal of clinical pathology, 102(2), 1994, pp. 237-241
The authors assessed the capability of assays of activated partial thr
omboplastin time (aPTT) for supporting clinical decision algorithms fo
r heparin therapies of varying complexity. Blood samples were collecte
d prospectively in three explicit management strategies from 100 seque
ntial patients for whom heparin dosage was adjusted for therapeutic mo
nitoring, femoral venous sheath removal after cardiac catheterization,
or heparinization after thrombolytic therapy. In two- and three-way d
ecision algorithms, conventional and point-of-care aPTT assays agreed
with heparin assays in approximately two thirds of cases, and the two
aPTT assays agreed in 80% or more of all cases. In six-way decision al
gorithms, the two aPTT assays agreed in only about half of all cases.
The authors conclude that the reliability of point-of-care aPTT assays
is similar to that of conventional assays. Both techniques can suppor
t two- and three-way decision algorithms but not some more complex pat
ient classifications.