M. Chetty et al., SMOKING AND BODY-WEIGHT INFLUENCE THE CLEARANCE OF CHLORPROMAZINE, European Journal of Clinical Pharmacology, 46(6), 1994, pp. 523-526
The population pharmacokinetic parameters of chlorpromazine (CPZ) in c
hronic schizophrenic patients were evaluated using 189 plasma concentr
ation measurements from 31 patients. A NONMEM analysis demonstrated th
at the clearance of CPZ depended on the patient's body weight. Cigaret
te smoking and cannabis smoking increased the clearance of CPZ. Chroni
c alcohol consumption and the concurrent use of anticholinergics did n
ot appear to influence the clearance of CPZ significantly.