SMOKING AND BODY-WEIGHT INFLUENCE THE CLEARANCE OF CHLORPROMAZINE

Authors
CHETTY M MILLER R MOODLEY SV
Citation
M. Chetty et al., SMOKING AND BODY-WEIGHT INFLUENCE THE CLEARANCE OF CHLORPROMAZINE, European Journal of Clinical Pharmacology, 46(6), 1994, pp. 523-526
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European Journal of Clinical Pharmacology → ACNP
ISSN journal
00316970
Volume
46
Issue
6
Year of publication
1994
Pages
523 - 526
Database
ISI
SICI code
0031-6970(1994)46:6<523:SABITC>2.0.ZU;2-W
Abstract
The population pharmacokinetic parameters of chlorpromazine (CPZ) in c hronic schizophrenic patients were evaluated using 189 plasma concentr ation measurements from 31 patients. A NONMEM analysis demonstrated th at the clearance of CPZ depended on the patient's body weight. Cigaret te smoking and cannabis smoking increased the clearance of CPZ. Chroni c alcohol consumption and the concurrent use of anticholinergics did n ot appear to influence the clearance of CPZ significantly.