APPLICATION OF CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY TO THE ANALYSIS OF URINE SAMPLES FROM ANIMALS AND MAN CONTAINING PARACETAMOL ANDPHENACETIN AND THEIR METABOLITES

Authors
ASHCROFT AE MAJOR HJ WILSON ID NICHOLLS A NICHOLSON JK
Citation
Ae. Ashcroft et al., APPLICATION OF CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY TO THE ANALYSIS OF URINE SAMPLES FROM ANIMALS AND MAN CONTAINING PARACETAMOL ANDPHENACETIN AND THEIR METABOLITES, Analytical communications, 34(2), 1997, pp. 41-43
Citations number
6
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical communications → ACNP
ISSN journal
13597337
Volume
34
Issue
2
Year of publication
1997
Pages
41 - 43
Database
ISI
SICI code
1359-7337(1997)34:2<41:AOCEMT>2.0.ZU;2-1
Abstract
Capillary electrophoresis, in combination with electrospray mass spect rometry (CE-ESMS), has been applied to the analysis of phenacetin and paracetamol and its metabolites in freeze dried urine, and solid phase extracts of urine, following administration to rat and man, Using CE- ESMS the detection of 2 pg of d(3)-paracetamol on column was possible. Phenacetin, paracetamol and paracetamol glucuronide and sulfate were all readily detectable in the samples, The CE-ESMS method was also use d to determine the extent of deacetylation/reacetylation of d(3)-acety l-labelled paracetamol in vivo.