THE COUNTERING OF DIAZOXIDE-INDUCED VASODILATATION BY TENOXICAM IN NORMAL VOLUNTEERS

The effect of the nonsteroidal anti-inflammatory drug, tenoxicam, on d iazoxide-induced lowering of standing diastolic blood pressure was exp lored in 10 normal volunteers. With diazoxide there was a significant fall in the 5-min standing diastolic pressure, i.e. a median drop of 1 5.5, 11.0, 9.5 and 7.0 mm Hg at 10, 35, 75 and 105 min, respectively b ut with the tenoxicam-diazoxide regimen this pressure did not differ s ignificantly from baseline at any time point. Tenoxicam did not modify the diazoxide-induced changes in blood glucose and plasma insulin. It may be that prostaglandins normally contribute to the lowering of per ipheral vascular resistance, or that acutely-administered diazoxide en hances the release of vasodilatory prostaglandins.