EVALUATION OF A MOLECULAR-IMPRINTED POLYMER FOR USE IN THE SOLID-PHASE EXTRACTION OF PROPRANOLOL FROM BIOLOGICAL-FLUIDS

Authors
MARTIN P WILSON ID MORGAN DE JONES GR JONES K
Citation
P. Martin et al., EVALUATION OF A MOLECULAR-IMPRINTED POLYMER FOR USE IN THE SOLID-PHASE EXTRACTION OF PROPRANOLOL FROM BIOLOGICAL-FLUIDS, Analytical communications, 34(2), 1997, pp. 45-47
Citations number
6
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical communications → ACNP
ISSN journal
13597337
Volume
34
Issue
2
Year of publication
1997
Pages
45 - 47
Database
ISI
SICI code
1359-7337(1997)34:2<45:EOAMPF>2.0.ZU;2-A
Abstract
The use of a polymer, prepared in the presence of racemic propranolol in order to form a 'molecular imprint', for the highly selective extra ction of the drug from a variety of aqueous media, including biologica l samples, is described, It is shown that the conditions chosen for el ution of the adsorbed propranolol are extremely important to ensure se lectivity, Thus eluents based on methanol-water 1% TEA proved to provi de greater selectivity than those based on methanol-water 1% TFA.