EFFECT OF COMBINED SUPPLEMENTATION OF MAGNESIUM-OXIDE AND PYRIDOXINE IN CALCIUM-OXALATE STONE FORMERS

A combined supplement of magnesium oxide (300 mg/day) and pyridoxine . HCl (10 mg/day) was given p.o. to 16 recurrent calcium oxalate (CaOx) stone formers, and its therapeutic efficacy was biochemically evaluat ed by measuring various parameters of blood (Na, K, Mg, urea, creatini ne, calcium, phosphate, uric acid, alanine transaminase, aspartate tra nsaminase and alkaline phosphatase) and urine (volume, pH, creatinine, Na, K, Mg, uric acid, calcium, phosphate, oxalate and citrate) at 0, 30, 60, 90 and 120 days of treatment. Serum Mg significantly (P<0.01) increased after 30 days of treatment and remained constant thereafter while other blood parameters were unaltered. Combined treatment led to a significant increase in the urinary excretion of Mg and citrate ove r pretreatment values while oxalate excretion showed a gradual and sig nificant decline during the therapy. The results confirmed the efficac y of MgO-pyridoxine supplementation in terms of changes in urinary exc retion of lithogenic and inhibitory components, leading to a significa nt (P<0.01) decrease in CaOx risk index from 0.09 +/- 0.04 at 0 day to 0.05 +/- 0.02 after 120 days of treatment.