H. Silver et al., THE EFFECT OF CHRONIC FLUVOXAMINE TREATMENT ON OVERNIGHT MELATONIN SECRETION IN MEDICATED CHRONIC-SCHIZOPHRENIC PATIENTS, Human psychopharmacology, 12(1), 1997, pp. 21-25
Overnight melatonin levels were measured in five male schizophrenic pa
tients on steady antipsychotic treatment following the addition of flu
voxamine. Melatonin secretion increased in the first week of treatment
and progressively decreased after 3 weeks. The findings are consisten
t with the development of tolerance in the processes underlying melato
nin secretion.