Eighteen children with West syndrome underwent MRI-examination of the
brain. Five children were examined twice. Myelination of ten regions o
f the brain was retrospectively assessed on the MRI-examinations. The
children could be divided in three groups of main diagnosis (cryptogen
ic West syndrome, tuberous sclerosis, pre-/perinatally acquired brain
lesions). Delays in myelination were found in 17 out of a total of 23
examinations. In children with cryptogenic West syndrome and with tube
rous sclerosis myelination was normal or only mildly delayed in the fi
rst month after onset of the spasms, but delays seemed to increase in
the course of the West syndrome in these groups. In children with pre-
or perinatally acquired brain lesions severe delays of myelination co
uld be found already in the first weeks after the onset of the West sy
ndrome. The assessment of myelination can therefore contribute to the
diagnosis and understanding of the underlying disease in children with
West syndrome.