Cj. Vanrensburg et al., IMPROVED DUODENAL-ULCER HEALING WITH PANTOPRAZOLE COMPARED WITH RANITIDINE - A MULTICENTER STUDY, European journal of gastroenterology & hepatology, 6(8), 1994, pp. 739-743
Objective: To compare the efficacy and tolerability of pantoprazole 40
mg (once daily in the morning) with ranitidine 300 mg (once daily at
bedtime) in duodenal ulcer healing. Design: Prospective multicentre, r
andomized, double-blind, parallel-group comparison. Patients: The stud
y included 199 outpatients aged from 18 to 75 years, with endoscopical
ly confirmed active duodenal ulcer disease. Methods: Endoscopy and sta
ndard laboratory assessments, including serum gastrin levels, were car
ried out at the beginning of the study, after 2 and, where applicable,
after 4 weeks. Results: Of the patients, 182 (98 on pantoprazole, 84
on ranitidine), median age 39 years, completed the study. Complete ulc
er healing in protocol-correct patients after 2 weeks was significantl
y higher (P<0.001) in patients given pantoprazole (61%) compared with
those given ranitidine (35%). After 4 weeks, the cumulative healing ra
tes were 97 and 81%, respectively (P<0.001, Cochran-Mantel/Haenszel me
thod). Ulcer healing occurred significantly faster with pantoprazole t
han with ranitidine (P<0.001, Uleman's U-test). Conclusions: Pantopraz
ole is significantly more effective than ranitidine for healing of duo
denal ulcer both at 2 and 4 weeks. There was no significant difference
between the two groups with respect to complete pain relief after 2 w
eeks of treatment. Both pantoprazole and ranitidine were well tolerate
d with no serious adverse events.