BACKGROUND: Epikeratophakia is a potentially reversible corneal surgic
al procedure that can correct refractive errors in children who are ap
hakic and poor candidates for intraocular lens implantation. The corre
ction of aphakia in the pediatric population poses specific problems b
ecause of associated amblyopia, METHODS: The clinical records of 61 co
nsecutive patients (82 eyes) treated for pediatric aphakia by epikerat
ophakia were reviewed retrospectively with a follow-up of 3 to 5 years
. For the purpose of analysis, the patients were divided into seven gr
oups. RESULTS: The overall success rate for epikeratophakia was 92%, b
ut with repeated surgery, the patient success rate was 93%. The averag
e refractive error at 1 year was +0.10 diopters (D), At 1 year, 68% of
eyes had a refraction within 1 D of emmetropia, In these growing eyes
, we documented an average myopic shift of -0.40 D during 4 years, A m
yopic shift occurred in 30.2% and a hyperopic shift in 9.4% of eyes. S
pectacle-corrected visual acuity at 3 years showed 36% of eyes seeing
20/40 or better, Visual acuity results in different groups varied with
the timing of epikeratophakia, density of amblyopia and parents' abil
ity to maintain the patching schedule, The most encouraging results ca
me from the treatment of monocular traumatic cataracts. In this group,
31% achieved visual acuities of 20/40 or better and 85% achieved 20/1
00 or better at final examination, Those with incomplete congenital ca
taracts also showed favorable results: 39% achieved 20/40 or better at
final examination, CONCLUSIONS: Follow-up of 3 to 5 years demonstrate
d that epikeratophakia can correct refractive errors safely and succes
sfully in aphakic children, either as a primary procedure, or as a sec
ondary procedure after cataract extraction.