PHASE-I TRIAL IN HUMANS OF AN OIL-BASED ADJUVANT SEPPIC MONTANIDE ISA-720

Authors
LAWRENCE GW SAUL A GIDDY AJ KEMP R PYE D
Citation
Gw. Lawrence et al., PHASE-I TRIAL IN HUMANS OF AN OIL-BASED ADJUVANT SEPPIC MONTANIDE ISA-720, Vaccine, 15(2), 1997, pp. 176-178
Citations number
4
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
15
Issue
2
Year of publication
1997
Pages
176 - 178
Database
ISI
SICI code
0264-410X(1997)15:2<176:PTIHOA>2.0.ZU;2-Y
Abstract
Seppic MONTANIDE ISA 720 is a metabolizable oil adjuvant that has give n good results in animals with recombinant malarial antigens. Twelve h uman volunteers were given increasing intramuscular doses of MONTANIDE ISA 720, ranging from 0.6 to 1.8 ml. The adjuvant was well tolerated with only minor effects, including tenderness, local swelling and disc omfort on use. MONTANIDE ISA 720 may prove to be an acceptable and eff ective adjuvant for use in people. Copyright (C) 1997 Elsevier Science Ltd.