J. Najda et al., THE ANTIOXIDANT ENZYMES ACTIVITY IN THE CONDITIONS OF SYSTEMIC HYPERSILICEMIA, Biological trace element research, 42(1), 1994, pp. 63-70
The effect of an excessive inorganic silicon oral intake on the activi
ty of basic antioxidant enzymes was studied in rats. Activities of sup
eroxide dismutase, catalase, and glutathione peroxidase were measured
in liver and kidney tissues of animals receiving per os sodium metasil
icate nonahydrate (Na2SiO3.9H(2)O) (Sigma, [St. Louis, MO]) dissolved
in their drinking water. A decrease of the activity of all the studied
enzymes was found in the samples derived from the experimental group.
The results obtained indicate the free oxygen radicals participation
in the potential pathologic events in the conditions of systemic hyper
silicemia.