CHROMOSOMAL LOCALIZATION OF 4 HUMAN VH1-LIKE PROTEIN-TYROSINE PHOSPHATASES

Four human protein-tyrosine phosphatase (PTPase) genes of the VH1-like subclass were cloned by low-stringency screening of a genomic library . These genes were localized to their respective chromosomes by G-band ing and fluorescence in situ hybridization. The genes were localized t o unique regions of different chromosomes: CL100, a stress-induced PTP ase, to 5q35; PAC-1, a mitogen-induced nuclear PTPase, to 2q11; hVH-3 to 10q25; and hVH-4 to 10q11. (C) 1994 Academic Press, Inc.