GLOBLET CELL CARCINOID OF THE APPENDIX

A 47-year-old man was admitted with appendicitis, and appendectomy was performed. On microscopic examination of the resected specimen, the p resence of goblet cell carcinoid in the tip of appendix was revealed. This tumor showed an aggressive nature with perineural and vascular in vasion around the appendiceal serosa. The tumor was composed of two ma in cell populations: mucin-producing (goblet cell type) and silver-pos itive cells (endocrine differentiation). Additionally, a few cells wer e also positive for serotonin and lysozyme, but negative for gastrin a nd ACTH. These findings suggest that goblet cell carcinoid share some functional and histologic characteristics with carcinoid tumors and ad enocarcinomas, although it is a distinct entity.