EFFICIENT PHOSPHATE-BINDING USING A COMBINATION OF GLUCONOLACTATE ANDCARBONATE CALCIUM SALTS

Although renal-failure-related hyperphosphataemia can be corrected by various phosphate binders, there remains a need for safer and more eff icient formulations to precipitate phosphate. This work describes both a theoretical approach and a phosphate precipitation test in order to design efficient binding calcium salts formulations. The results show that the combination of a soluble calcium salt (the gluconolactate) a nd a proton-consuming calcium salt (the carbonate) can precipitate pho sphate effectively. Furthermore, the theoretical computations correlat e well with the ability of the salt to bind phosphate in vitro.