STABILITY OF CIPROFLOXACIN IN 5-PERCENT DEXTROSE AND NORMAL SALINE INJECTIONS

The stability of ciprofloxacin in 5% dextrose and normal saline i.v. a dmixtures have been determined using a stability-indicating high perfo rmance liquid chromatographic assay method reported in the literature. The solutions were stored in plastic bags, a procedure being used in hospitals for in or out-patient therapy. The solutions were stable for at least 3 months when stored at room or refrigerator temperatures. T hey remained clear throughout the study and their pH values did not ch ange. The expiry date recommended by the manufacturer appears to be ve ry conservative from a chemical viewpoint.