COMPARISON OF UPTAKE OF TC-99M-ALKYLISONITRILES IN THE RAT 9L GLIOSARCOMA TUMOR-MODEL

The accumulation of three Tc-99m(I) alkyl isonitriles was compared in vitro and in vivo using 9L, gliosarcoma cells. In vitro, the uptake of Tc-99m-EIBI and Tc-99m-EPI was higher than that of Tc-99m-MIBI. In vi vo, however, there was no difference in the tumor concentration at 15 or 60 min postinjection and only a small difference at 24 h The differ ences in uptake observed in vitro are apparently offset in vivo by dif ferences in delivery of the tracers to the tumor. Copyright (C) 1997 E lsevier Science Inc.