CHARACTERIZATION OF 6-DEOXY-6-IODO-D-GLUCOSE - A POTENTIAL NEW TOOL TO ASSESS GLUCOSE-TRANSPORT

Authors
HENRY C TANTI JF GREMEAUX T MORIN C VANOBBERGHEN E COMET M LEMARCHANDBRUSTEL Y
Citation
C. Henry et al., CHARACTERIZATION OF 6-DEOXY-6-IODO-D-GLUCOSE - A POTENTIAL NEW TOOL TO ASSESS GLUCOSE-TRANSPORT, Nuclear medicine and biology, 24(1), 1997, pp. 99-104
Citations number
48
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
24
Issue
1
Year of publication
1997
Pages
99 - 104
Database
ISI
SICI code
0969-8051(1997)24:1<99:CO6-AP>2.0.ZU;2-#
Abstract
6-deoxy-6-iodo-D-glucose (6-DIG) was rapidly taken up by adipocytes. I nsulin increased 6-DIG transport in adipocytes isolated from both rats and mice. This stimulation was more important in rat than in mouse ad ipocytes, in agreement with their respective amount of Glut 4 transpor ters. In two insulin-resistant states, the biological behavior of 6-DI G and 3-O-methyl-D-glucose was similar. These results indicated that 6 -DIG, which was transported into the cells via the glucose transporter s, could be potentially useful to measure modifications of glucose tra nsport. Copyright (C) 1997 Elsevier Science Inc.