SUSTAINED-RELEASE ISRADIPINE COMPARED WITH SPIRAPRIL IN THE TREATMENTOF ELDERLY PATIENTS WITH ISOLATED SYSTOLIC HYPERTENSION

Authors
TOMLINSON B WOO J CRITCHLEY JAJH OR KKH CHAN TYK SANDERSON JE
Citation
B. Tomlinson et al., SUSTAINED-RELEASE ISRADIPINE COMPARED WITH SPIRAPRIL IN THE TREATMENTOF ELDERLY PATIENTS WITH ISOLATED SYSTOLIC HYPERTENSION, American journal of hypertension, 7(7), 1994, pp. 190000035-190000039
Citations number
NO
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
American journal of hypertension → ACNP
ISSN journal
08957061
Volume
7
Issue
7
Year of publication
1994
Part
2
Supplement
S
Pages
190000035 - 190000039
Database
ISI
SICI code
0895-7061(1994)7:7<190000035:SICWSI>2.0.ZU;2-A
Abstract
The benefits of treating isolated systolic hypertension (ISH) have bee n established, but the most appropriate choice of drug is still uncert ain. For this reason, a sustained-release formulation of isradipine wa s compared with spirapril in a double-blind randomized study in elderl y Chinese patients with ISH. The dosage was titrated if necessary afte r 4 weeks of treatment. The reduction in systolic/diastolic blood pres sure after 8 weeks was similar for both treatments-20/10 mm Hg with is radipine versus 24/6 mm Hg with spirapril-measured in the supine posit ion. There were no orthostatic symptoms and both treatments were well tolerated.