Ma. Gratton et al., AGE-RELATED DECREASES IN ENDOCOCHLEAR POTENTIAL ARE ASSOCIATED WITH VASCULAR ABNORMALITIES IN THE STRIA VASCULARIS (VOL 94, PG 116, 1996), Hearing research, 102(1-2), 1996, pp. 179
The density and diameter of strial capillaries were assessed in whole-
mount preparations of the cochlear lateral wall from 18 gerbils aged i
n quiet for at least 36 months. Following morphometric analysis, histo
pathologic changes in selected regions of the lateral wall were examin
ed by light and transmission electron microscopy. Alterations in stria
l vasculature were compared with the endocochlear potential (EP) measu
rements from the same ear. Vascular degeneration occurred in a segment
al fashion in that regions of atrophic capillaries were found througho
ut the cochlea but primarily in the apical and lower basal turns and i
n the hook. The amount of stria with normal capillaries varied greatly
among the aged ears, ranging from 19 to 87%. The resting EP also vari
ed markedly, ranging from 23 to 83 mV. Little correlation was found be
tween vascular alterations and the corresponding EP value from individ
ual cochlear turns. However, significant correlations were found betwe
en the total strial area with normal vasculature and both the mean EP
value and that recorded at either the round window or first turn in th
at ear.